| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: presented group of inventions refers to medicine. What is presented is a pharmaceutical composition representing a tablet formulation containing ritonavir in a first layer and atazanavir in a second layer, and a polymer. What is presented is a method for preparing the above pharmaceutical composition wherein a hot melt of rinonavir is extruded to prepare an extrudate to be placed into the first tablet layer, and atazanavir - into the second layer; the first and second layers are combined providing a single multilayer tablet. What is presented is a composition prepared by the method described above to be used in treating HIV or AIDS, and a method of treating HIV or AIDS.EFFECT: presented group of inventions is effective in creating the multilayer tablet providing a good bioavailability for ritonavir, wherein atazanavir is not degraded in preparation.19 cl, 5 tbl, 4 ex |
