发明名称 |
PREDICTIVE MARKER OF DNMT1 INHIBITOR THERAPEUTIC EFFICACY AND METHODS OF USING THE MARKER |
摘要 |
Provided herein are methods for predicting efficacy of a DNA (cytosine-5)methyltransferase1 (DNMT 1) inhibitor treatment in a subject having a cancer, methods of identifying a subject having a cancer that is more likely to respond to a DNMTI inhibitor treatment, and methods of selecting a treatment for a subject having a cancer that include determining a level of SOX9 in a sample containing cells from a subject having a cancer. Also provided are methods of treating a subject having a cancer that include selectively administering a DNMTI inhibitor to a subject having cancer determined to have an elevated level of SOX9 in cells from the subject compared to a reference level. Also provided are antibodies and antigen-binding antibody fragments that specifically bind to SOX9, and nucleic acid sequences that contain at least 10 nucleotides complementary to a contiguous sequence present in a SOX9 nucleic acid for use in these methods. |
申请公布号 |
WO2012122219(A3) |
申请公布日期 |
2014.02.27 |
申请号 |
WO2012US27982 |
申请日期 |
2012.03.07 |
申请人 |
UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION;BATES, PAULA J.;MALIK, MOHAMMAD TARIQ;RINALDO, FRANCESCA |
发明人 |
BATES, PAULA J.;MALIK, MOHAMMAD TARIQ;RINALDO, FRANCESCA |
分类号 |
C12Q1/68;A61K48/00;C12N5/00;C12N9/00 |
主分类号 |
C12Q1/68 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|