发明名称 |
IgA CD4i ANTIBODIES AND METHODS OF TREATMENT USING SAME |
摘要 |
The present invention relates to isolated IgA antibodies, or fragments thereof, which have variable domains derived from an antibody that specifically binds to a CD4-induced (CD4i) epitope. In particular, the isolated IgA antibodies display enhanced neutralization activity relative to their IgG, non-chimeric counterparts. The invention also provides methods for therapy with the isolated IgA antibodies for the treatment of a subject having a viral infection or having an increased risk of a viral infection. |
申请公布号 |
WO2013188870(A3) |
申请公布日期 |
2014.02.27 |
申请号 |
WO2013US46124 |
申请日期 |
2013.06.17 |
申请人 |
BETH ISRAEL DEACONESS MEDICAL CENTER, INC. |
发明人 |
CAVACINI, LISA;POSNER, MARSHALL;YU, XIAOCONG |
分类号 |
A61K39/395;A61P31/18;C07K16/10 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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