| 摘要 |
The invention is directed to methods and metric suitable for use in determining the solubility, expression and usability of a polypeptide encoded by a nucleic acid sequence. In certain aspects, the invention also relates to methods for introducing modifications in a polypeptide, for example through substitution of one or more codons in the nucleic acid sequence encoding the polypeptide, to increase or decrease the solubility, expression or usability of the polypeptide. |
| 申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK;RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY |
发明人 |
HUNT, JOHN, FRANCIS;PRICE, WILLIAM, NICHOLSON;MONTELIONE, GAETANO, T.;BOEL, GREGORY, P.;ACTON, THOMAS |
