发明名称 |
GLP-1 PROMOTER MEDIATED INSULIN EXPRESSION FOR THE TREATMENT OF DIABETES |
摘要 |
Insulin gene therapy is one of many envisioned alternative treatments of diabetes. Diabetes gene therapy would be possible if insulin could be produced in a regulated and specifically in a sensitive manner dependent on the blood glucose level. Therefore, the present invention relates to a method for the isolation of GLP-1 expressing cells, to nucleic acids sequence construction or vectors useful for isolating GLP-1 expressing cell and to the GLP-1 expressing cells isolated therewith. Furthermore, the invention relates to a method of nucleic acids sequence construction or vectors under the control of the GLP-1 promoter expressing insulin in a recombinant GLP-1 expressing cell line. The cells of the present invention are particular useful for the treatment of diabetes and may be used in a gene therapy approach to treat diabetes and other disorders related to the nutrient metabolism. |
申请公布号 |
EP2625270(A4) |
申请公布日期 |
2014.02.26 |
申请号 |
EP20110830970 |
申请日期 |
2011.10.05 |
申请人 |
UNIVERSITI PUTRA MALAYSIA (UPM) |
发明人 |
HAJLAHMAD, ZALINAH;OMAR, ABDUL, RAHMAN;RASOULI, MINA |
分类号 |
C12N15/00;A61K48/00 |
主分类号 |
C12N15/00 |
代理机构 |
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