发明名称 |
PROSTATE-SPECIFIC MEMBRANE ANTIGEN BINDING PROTEINS AND RELATED COMPOSITIONS AND METHODS |
摘要 |
<p>The present invention relates to mono-specific and multi-specific polypeptide therapeutics that specifically target cells expressing prostate-specific membrane antigen (PSMA) and are useful for the treatment of prostate cancer (e.g., castrate-resistant prostate cancer), tumor-related angiogenesis or benign prostatic hyperplasia (BPH). In one embodiment, the multi-specific polypeptide therapeutics bind both PSMA-expressing cells and the T-cell receptor complex on T cells to induce target-dependent T-cell cytotoxicity, activation and proliferation.</p> |
申请公布号 |
EP2699596(A2) |
申请公布日期 |
2014.02.26 |
申请号 |
EP20120773598 |
申请日期 |
2012.04.20 |
申请人 |
EMERGENT PRODUCT DEVELOPMENT SEATTLE, LLC |
发明人 |
BLANKENSHIP, JOHN W.;SEWELL, ELAINE TODD;TAN, PHILIP |
分类号 |
C07K16/00;A61K39/395;A61P35/00;C07K16/28;C07K16/30 |
主分类号 |
C07K16/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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