MODEL MOUSE OF ATTENTION DEFICIT HYPERACTIVITY DISORDER, METHOD FOR INVESTIGATING EFFECTS FOR PREVENTING AND ALLEVIATING ATTENTION DISORDER USING THE MODEL MOUSE, AND METHOD FOR TREATING ATTENTION DISORDER BY SUPPRESSING T-TYPE CALCIUM CHANNEL

摘要

The present invention relates to an Attention deficit and hyperactivity disorder(ADHD) mouse model and a screening method for a composition for the prevention and treatment of attention deficit disease. The mouse model constructed by inserting cobalt wire in the right side of the frontal lobe is very useful as the ADHD mouse model, and the said ADHD mouse model can be effectively used for the screening of an agent for the treatment of attention deficit disease since the mouse demonstrated brain wave with low frequency, hyperactivity, and cognitive impairment, which are characteristic symptoms of attention deficit disease, when ethosuximide, one of T-type calcium channel blockers, was administered. Therefore, the composition comprising a T-type calcium channel blocker was also confirmed to be effectively used for the prevention and treatment of attention deficit disease.