发明名称 |
PEPTIDE INHIBITORS OF CD40L SIGNALING AND USES THEREFOR |
摘要 |
<p>The present invention provides compositions comprising peptidyl inhibitors of CD40L-dependent signaling that are not derived from a natural binding partner of CD40L such as CD40, or from a native CD40-CD40L interface. More particularly, the peptidyl inhibitors of the present invention are derived from natural sources that do not express CD40-Cd40L costimulatory pathways. The invention also provides synthetic derivatives and analogs of the peptidyl inhibitors having enhanced binding affinity for CD40L or enhanced inhibitory activity relative to their parent molecules.</p> |
申请公布号 |
EP2616480(A4) |
申请公布日期 |
2014.02.26 |
申请号 |
EP20110824367 |
申请日期 |
2011.09.16 |
申请人 |
PHYLOGICA LIMITED |
发明人 |
WATT, PAUL MICHAEL;HOPKINS, RICHARD;HOFFMANN, KATRIN |
分类号 |
C07K14/195;A61K38/10;A61K38/16;A61P7/04;A61P37/00;C07K7/08;C07K14/205;C07K14/21;C07K14/215;C07K14/22;C07K14/235;C07K14/245;C07K14/255;C07K14/32 |
主分类号 |
C07K14/195 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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