发明名称 |
Polyconjugates for in vivo delivery of polynucleotides |
摘要 |
The present invention is directed to compounds, compositions, and methods useful for delivering polynucleotides or other cell-impermeable molecules to mammalian cells. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti-aggregation, and transfection activities into small biocompatible in vivo delivery vehicles. The use of multiple reversible or labile linkages connecting component parts provides for physiologically responsive activity modulation. |
申请公布号 |
US8658211(B2) |
申请公布日期 |
2014.02.25 |
申请号 |
US201213368796 |
申请日期 |
2012.02.08 |
申请人 |
ROZEMA DAVID B.;WAKEFIELD DARREN H.;LEWIS DAVID L.;KLEIN JASON;WONG SO;WOLFF JON A.;HAGSTROM JAMES E.;ARROWHEAD MADISON INC. |
发明人 |
ROZEMA DAVID B.;WAKEFIELD DARREN H.;LEWIS DAVID L.;KLEIN JASON;WONG SO;WOLFF JON A.;HAGSTROM JAMES E. |
分类号 |
A61K9/14;C07D207/444;C07H21/02;C12N15/00;C12N15/11 |
主分类号 |
A61K9/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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