Low affinity FcgammaR deficient mice

摘要

Genetically modified non-human animals and methods and compositions for making and using them are provided, wherein the genetic modification comprises a deletion of the endogenous low affinity FcgammaR locus, and wherein the mouse is capable of expressing a functional FcRgamma-chain. Genetically modified mice are described, including mice that express low affinity human FcgammaR genes from the endogenous FcgammaR locus, and wherein the mice comprise a functional FcRgamma-chain. Genetically modified mice that express up to five low affinity human FcgammaR genes on accessory cells of the host immune system are provided.