发明名称 |
Biocatalysts for manufacturing duloxetine alcohol |
摘要 |
The present invention relates to novel phenylethanol dehydrogenase mutants, to a method for the manufacture thereof; to coded nucleic acid sequences therefor, to expression cassettes, to vectors and recombinant microorganisms that contain said sequences; to a method for the biocatalytic synthesis of substituted, optically active alcohols and to the use of said mutants; and particularly to a method for manufacturing duloxetine alcohol or duloxetine, comprising a synthesis step catalyzed biocatalytic by said mutants. |
申请公布号 |
US8658400(B2) |
申请公布日期 |
2014.02.25 |
申请号 |
US200913140255 |
申请日期 |
2009.12.16 |
申请人 |
SCHNEIDER NINA;HOEFFKEN HANS WOLFGANG;BASF SE |
发明人 |
SCHNEIDER NINA;HOEFFKEN HANS WOLFGANG |
分类号 |
C12P17/00;C07D333/12;C07H21/04;C07K1/00;C12N1/20;C12N9/04;C12N15/00;C12P7/02;C12P21/06 |
主分类号 |
C12P17/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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