METHOD FOR TUMOUR GROWTH INHIBITION IN EXPERIMENT

摘要

FIELD: medicine.SUBSTANCE: invention refers to medicine, namely to experimental studies in oncology and may be used for assessing the anti-tumour action of metal nanoparticles (NP). An iron nanoparticle suspension 1.25 mg/kg is introduced into grafted Pliss lymphosarcoma intratumourally. That is followed by the paratumoural introduction of methotrexate 0.2 mg/kg. The tumour is locally heated to temperature 42-43°C using an electromagnetic UHF emission at frequency 12.7 MHz for 10 minutes. The therapy requires 5 such sessions in total every 48 hours. That is followed by calculating an effectiveness index, a complete regression percentage and Pliss lymphosarcoma growth inhibition percentage.EFFECT: method intensifies the antitumor effect of the thermal chemotherapy without increasing body toxicity.2 tbl