发明名称 |
ARYLETHYNYL PYRIMIDINES |
摘要 |
The present invention relates to ethynyl derivatives of formula I wherein R1 is hydrogen or halogen; R2 is C1-3-alkyl or -(CH2)m-O-CH3; n is 2 or 3; m is 1 or 2; or to a pharmaceutically acceptable acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof. It has been found that the compounds of general formula I are allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5) with improved properties for the treatment of schizophrenia, cognitive diseases, fragile X syndrome or autism. |
申请公布号 |
WO2014026880(A1) |
申请公布日期 |
2014.02.20 |
申请号 |
WO2013EP66443 |
申请日期 |
2013.08.06 |
申请人 |
F. HOFFMANN-LA ROCHE AG;HOFFMANN-LA ROCHE INC. |
发明人 |
JAESCHKE, GEORG;LINDEMANN, LOTHAR;STADLER, HEINZ;VIEIRA, ERIC |
分类号 |
C07D403/04;A61K31/506;A61P25/00 |
主分类号 |
C07D403/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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