发明名称 |
NORBORNENE MODIFIED PEPTIDES AND THEIR LABELLING WITH TETRAZINE COMPOUNDS |
摘要 |
The invention relates to a polypeptide comprising an amino acid having a norbornene group. Suitably said norbornene group is present as an amino acid residue of a norbornene lysine. The invention also relates to a method of producing a polypeptide comprising a norbornene group, said method comprising genetically incorporating an amino acid comprising a norbornene group into a polypeptide. The polypeptide comprising the norbornene group can be specifically labelled by inverse electron demand Diels-Alder reaction with a tetrazine compound. |
申请公布号 |
WO2013108044(A8) |
申请公布日期 |
2014.02.20 |
申请号 |
WO2013GB50121 |
申请日期 |
2013.01.21 |
申请人 |
MEDICAL RESEARCH COUNCIL;NORTH CAROLINA STATE UNIVERSITY |
发明人 |
CHIN, JASON;DEITERS, ALEXANDER |
分类号 |
C07K1/13;A61K49/00;C12P21/02 |
主分类号 |
C07K1/13 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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