摘要 |
<p>Processes for manufacturing dihalopyridines without the use of copper salts are described. Additional processes for manufacturing dihalopyridines from niacinamide are described. In a preferred embodiment the dihalopyridine is prepared by adding a first liquid mixture comprising a metal nitrite salt to a second liquid mixture comprising a 3-amino-2- halopyridine, a hydrohalic acid and an iron(lll) compound.</p> |