发明名称 |
Extracellular histones as biomarkers for prognosis and molecular targets for therapy |
摘要 |
<p>Hyper-inflammatory responses can lead to a variety of diseases including sepsis. It is now shown that extracellular histones released in response to inflammatory challenge are mediators contributing to endothelial dysfunction, organ failure and death during sepsis. As such, they can be targeted pharmacologically by inhibitors, as well as used as biomarkers for prognosis of sepsis and other diseases.</p> |
申请公布号 |
AU2008323947(B2) |
申请公布日期 |
2014.02.20 |
申请号 |
AU20080323947 |
申请日期 |
2008.11.06 |
申请人 |
OKLAHOMA MEDICAL RESEARCH FOUNDATION |
发明人 |
ZHANG, XIAOMEI;ESMON, CHARLES T.;XU, JUN |
分类号 |
A61K38/17;A61K39/395;G01N33/53 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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