发明名称 |
HIGH PURITY 2-[4-(3- OR 2-FLUOROBENZYLOXY)BENZYLAMINO] PROPANAMIDES AND METHODS OF USE THEREOF |
摘要 |
A process for obtaining therapeutically active 2-[4-(3- and 2-(fluorobenzyloxy)benzylamino]propanamides, and their salts with pharmaceutically acceptable acids with high purity degree, in particular, with a content of dibenzyl derivatives impurities lower than 0.03%, preferably lower than 0.01% by weight. The process is carried out by submitting the Schiff bases intermediates 2-[4-(3- and 2-fluorobenzyloxy)benzylideneamino]propanamides to a reduction reaction with a reducing agent selected from sodium borohydride and potassium borohydride in an appropriate amount of an organic solvent selected from C1-C5 lower alkanols, allowing the formation and presence during a substantial position of the reduction reaction course of a suspension of the Schiff base into the saturated solution of the Schiff base into the same organic solvent. |
申请公布号 |
US2014051758(A1) |
申请公布日期 |
2014.02.20 |
申请号 |
US201313961693 |
申请日期 |
2013.08.07 |
申请人 |
NEWRON PHARMACEUTICALS S.P.A. |
发明人 |
BARBANTI ELENA;FARAVELLI LAURA;SALVATI PATRICIA;CANEVOTTI RENATO;PONZINI FRANCESCO |
分类号 |
C07C231/24;A61K31/165;A61K31/197;A61K31/198;A61K45/06 |
主分类号 |
C07C231/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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