发明名称 |
SCAVENGER RECEPTOR UPTAKE FOR FABRY DISEASE ENZYME REPLACEMENT THERAPY |
摘要 |
The present invention relates to a composition comprising a lysosomal enzyme conjugated to a negatively charged scavenger receptor ligand. In some embodiments, the lysosomal enzyme is conjugated to the scavenger receptor ligand by way of a linker. The present invention also relates to a composition comprising lysosomal enzyme encapsulated by a liposome, said liposome externally comprising a negatively charged scavenger receptor ligand. The invention further encompasses a method of treating a lysosomal storage disease with the compositions listed above. The invention further encompasses a method of treating a lysosomal storage disease with an acylated, acetylated, or aconitylated lysosomal enzyme. |
申请公布号 |
US2014050666(A1) |
申请公布日期 |
2014.02.20 |
申请号 |
US201313970551 |
申请日期 |
2013.08.19 |
申请人 |
RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEWYORK |
发明人 |
CALHOUN DAVID H.;GILCHRIST LANE |
分类号 |
C12N9/96;A61K9/127;A61K38/47;A61K49/00 |
主分类号 |
C12N9/96 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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