Specific molecules clinging to a lure

摘要

Identification of a ligand that bind specifically to a receptor molecule comprises providing an immobilized receptor molecule, contacting the immobilized molecule with a solution containing a library of target molecule, contacting the immobilized receptor molecules that are bound to the target molecule with at least a competitor molecule, increasing the number of target molecules that are bound to the receptor molecule, repeating the above steps and identifying the structure of the molecule remaining on the receptor molecule. Identification of a ligand that bind specifically to a receptor molecule comprises (a) providing an immobilized receptor molecule, (b) contacting the immobilized molecule acting as a receptor molecule with a solution that contains a library of target molecule, (c) contacting the immobilized receptor molecules that are bound to the target molecule with at least a competitor molecule as a specificity-exhibiting washing step, (d) increasing the number of target molecules that are bound to the receptor molecule even after contacting the immobilized receptor molecule that are bound to the target molecule in contact with the competitor molecule, and (e) repeating the above steps and identifying the structure of the molecule remaining on the receptor molecule after the repeating step. Independent claims are included for: (1) a protein comprising fully defined 12 amino acid sequence (SEQ ID NO: 1-5) as given in the specification; and (2) a therapeutic agent that exhibits a structure according to one of SEQ ID NO: 1-5. - ACTIVITY : Cytostatic; Anti-HIV; Antiinflammatory; Hepatotropic; Virucide. - MECHANISM OF ACTION : None given.