发明名称 |
Methods of NAD-dependent deacetylation of a lysine residue in a protein |
摘要 |
Methods of NAD-dependent of at least one lysine residue in an acetylated protein are disclosed. The methods include combining the acetylated protein with an isolated Sir2 protein or fragment that includes a core domain of the Sir2 protein. The Sir2 protein or fragment of the Sir2 protein can include a human Sir2 protein or a fragment of a human Sir2 protein. |
申请公布号 |
US8652797(B2) |
申请公布日期 |
2014.02.18 |
申请号 |
US20080209847 |
申请日期 |
2008.09.12 |
申请人 |
GUARENTE LEONARD;IMAI SHIN-ICHIRO;ARMSTRONG CHRISTOPHER;MASSACHUSETTS INSTITUTE OF TECHNOLOGY |
发明人 |
GUARENTE LEONARD;IMAI SHIN-ICHIRO;ARMSTRONG CHRISTOPHER |
分类号 |
C12Q1/02;A61K38/17;C12N9/00;C12Q1/48;G01N33/66 |
主分类号 |
C12Q1/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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