| 摘要 |
Compounds of formula (l): (see formula I) wherein R1 is selected from the group consisting of CO2H and a carboxylic acid or carboxylate bioisostere; R2 is selected from the group consisting of an amino acid side chain and a group R a-(CHR')x-A-(CH2)y-; and R3 is selected from the group consisting of C1-6alkyl, C2-6alkenyl, C2-6alkynyl, cycloalkyl, cycloalkenyl, aryl, heterocyclyl, heteroaryl and a group R d-(CH2)p-W-(CH2)q-; and wherein R4, R5, R a, R1 , A, R d, W, n, m, x, y, p and q are as defined herein; and pharmaceutically acceptable salts and prodrugs thereof; are disclosed herein. Further disclosed are conjugates and compositions comprising such compounds, and uses thereof for regulating cell death, or treatment or prophylaxis of a pro-survival Bcl-2 family member mediated disease or condition. |
