发明名称 |
Process for the production of etravirine |
摘要 |
A novel process for the preparation of Etravirine comprises the condensing of ethyl cyanoacetate with N-cyanophenylguanidine to obtain an -OH compound of formula (II), which is further converted to a leaving group of formula (III). The compound of formula (III) is optionally protected and brominated to yield compound of formula (IV). The condensation of formula (IV) with 3,5-dimethyl-4-hydroxybenzonitrile yields a compound of formula (VI), and an optional deprotection of the compound of formula (VI) results in Etravirine. |
申请公布号 |
US8653266(B2) |
申请公布日期 |
2014.02.18 |
申请号 |
US201213456319 |
申请日期 |
2012.04.26 |
申请人 |
GORE VINAYAK;BHARATI CHOUDHARI;HUBLIKAR MAHESH;BANSODE PRAKASH;SINORE SANDIP;MYLAN LABORATORIES LIMITED |
发明人 |
GORE VINAYAK;BHARATI CHOUDHARI;HUBLIKAR MAHESH;BANSODE PRAKASH;SINORE SANDIP |
分类号 |
C07D239/24 |
主分类号 |
C07D239/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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