发明名称 |
Conformational entropy in molecular recognition |
摘要 |
The present invention provides methods for the determination of the degree of molecular recognition of a protein with a ligand, including a first protein with a second protein. The methods may comprise determining the squared generalized order parameter (hereinafter, O) for at least one intramolecular bond of the first protein. The protein is then formed into a complex with a ligand. The value or values of O2 for the said at least one bond of the protein is then determined while the protein and the ligand are in the complex. The O value or values determined for the protein while the protein and the ligand are in a complex are compared or related to the O value or values determined for the uncomplexed protein. |
申请公布号 |
US8652790(B2) |
申请公布日期 |
2014.02.18 |
申请号 |
US20080669626 |
申请日期 |
2008.07.18 |
申请人 |
VALENTINE KATHLEEN G.;MARLOW MICHAEL;WAND ANDREW J.;FREDERICK KENDRA K.;THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA |
发明人 |
VALENTINE KATHLEEN G.;MARLOW MICHAEL;WAND ANDREW J.;FREDERICK KENDRA K. |
分类号 |
G01N31/00;G01N33/53;G06F19/16;G06F19/18 |
主分类号 |
G01N31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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