| 摘要 |
The present invention includes an article of manufacture or device, or related system, comprising a heterogeneous surface for selective analyte sensing or separation. Such an article can comprise a surface member and a plurality of spaced components extending therefrom and coupled thereto, such a surface member and spaced components providing a surface heterogeneity selected from different electrostatic interactions, different non-electrostatic interactions and a combination of such interactions, such that the interactions are at least partially sufficient for selective analyte interaction and/or separation. Each such component extension can be of a nanometer dimension about the Debye length of a medium comprising an analyte particle exposed to such a surface. An analyte particle, optionally of a mixture of particles, can be dimensioned from about 30 nm to 20 mum. In some embodiments, the extended components have a density at least partially sufficient for interaction of a single such component or multiple components with a single analyte particle, at a given Debye length. In other embodiments, such components have an average spatial density at least partially sufficient for selective particle interaction and/or separation. |
