摘要 |
The present application relates to novel, anti-C4,4a binder-drug conjugates (ADCs) of N,N-dialkyl auristatins, to effective metabolites of said ADCs, to methods for producing said ADCs, to the use of said ADCs for treating and/or preventing diseases, and to the use of said ADCs for producing pharmaceuticals for treating and/or preventing diseases, in particular hyperproliferative and/or angiogenic diseases, such as cancers. Such treatments can be carried out as monotherapy or in combination with other pharmaceuticals or additional therapeutic measures. |
申请人 |
SEATTLE GENETICS, INC. |
发明人 |
THIERAUCH, KARL-HEINZ;SCHUHMACHER, JOACHIM;WILLUDA, JÖRG;LERCHEN, HANS-GEORG;HEISLER, IRING;KOPITZ, CHARLOTTE CHRISTINE;EL SHEIKH, SHERIF;LINDEN, LARS;HARRENGA, AXEL;GREVEN, SIMONE;MAHLERT, CHRISTOPH;STELTELUDWIG, BEATRIX;GOLFIER, SVEN;BEIER, RUDOLF;BRUDER, SANDRA;PETRUL, HEIKE;JÖRISSEN, HANNAH;BORKOWSKI, SANDRA |