| 摘要 |
PROBLEM TO BE SOLVED: To provide, in various embodiments, systems, devices and methods relating to ex-vivo organ care.SOLUTION: The method uses lactate measurement in arterial and venous blood lines of an organ care system heart perfusion device to evaluate: 1) an overall perfusion status of an isolated heart and 2) a metabolic status of an isolated heart and 3) an overall vascular patency of an isolated donor heart. The aspect of the present invention uses the property of myocardial cell's unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen. |
