发明名称 |
METHOD FOR LOWERING THE VISCOSITY OF HIGH-CONCENTRATION PROTEIN SOLUTIONS |
摘要 |
Use of a compound of formula (I), at a concentration in the final formulation of between 10 and 250 mM: formula (I), for lowering the viscosity of a solution that is difficult to inject of at least one protein comprising at least one antibody fragment whereof the concentration is between 50 and 350 mg/mL and whereof the pH is between 5 and 8, by a value of at least 15% relative to the viscosity of a solution of at least one protein comprising at least one antibody fragment of the same concentration and of the same pH not containing said compound. It also concerns the method for lowering viscosity consisting of preparing a solution comprising a compound of formula (I) and a protein comprising at least one antibody fragment whereof the concentration is between 50 and 350 mg/mL and whereof the pH is between 5 and 8. |
申请公布号 |
WO2014023816(A1) |
申请公布日期 |
2014.02.13 |
申请号 |
WO2013EP66685 |
申请日期 |
2013.08.09 |
申请人 |
ADOCIA |
发明人 |
DAUTY, EMMANUEL;BALLET, THOMAS;SOULA, REMI |
分类号 |
A61K39/00;A61K47/06 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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