PHOSPHOINOSITIDE 3-KINASE INHIBITORS WITH A ZINC BINDING MOIETY

摘要

PHOSPHOINOSITIDE3-KINASEINHIBITORSWITHAZINCBINDINGMOIETYTheinstantapplicationrelatestodeazapurines,thienopyrimidinesandfuropyrimidines with zinc-binding moiety based derivatives and their use in thetreatment of phosphoinositide 3 -kinase related diseases and disorders such ascancer. The instant application further relates to the the treatment of histonedeacetylase related disorders and diseases related to both histone deacetylase and PHOSPHOINOSITIDE 3-KINASE INHIBITORS WITH A ZINC BINDING MOIETYThe instant application relates to deazapurines, thienopyrimidines andfuropyrimidines with zinc-binding moiety based derivatives and their use inthe treatment of phosphoinositide 3 -kinase related diseases and disorderssuch as cancer. The instant application further relates to the thetreatment of histone deacetylase related disorders and diseases related toboth histone deacetylase and phosphoinositide 3-kinase.