PROCESS FOR THE ENZYMATIC SYNTHESIS OF (7S)-1-(3,4-DIMETHOXYBICYCLO[4.2.0]OCTA-1,3,5-TRIEN-7-YL) N-METHYL METHANAMINE, AND APPLICATION IN THE SYNTHESIS OF IVABRADINE AND SALTS THEREOF

摘要

PROCESS FOR THE ENZYMATIC SYNTHESIS OF (7S)-143,4-DIMETHOXYBICYCLO[4.2.010CTA4,3,5-TRIEN-7-YL) N-METHYL METHANAMINE,AND APPLICATION IN THE SYNTHESIS OF IVABRADINE AND SALTS THEREOFProcess for the enzymatic synthesis of the compound of formula (I),(7S)-1-(3,4-d nethoxy- bicyclo[4.2.0]octa-1,3,5-trien-7-y1) N-methylmethanamine: H3 C- (1) and application in the synthesis of ivabradineand addition salts thereof with a pharmaceutically acceptable acid.No figure.