| 摘要 |
<p>An apparatus for measuring the concentration of an analyte in a sample extracted from the skin of a patient comprises a collection chamber 3 adjacent to the skin; a radiation source 7 configured to irradiate the sample in the collection chamber 3; a reflector 4 configured to reflect incident radiation back through the sample; and a sensor 10 configured to measure the radiation emitted from the sample. The reflector 4 may shield the skin from the incident radiation and have a convoluted or perforated shape to permit sufficient diffusion of the extracted analyte to all parts of the surface of the reflector from its edges. In a further apparatus the reflector 4 can be implanted beneath an outer layer of the skin so that instead of being extracted, the sample can be measured in vivo. Possibilities for the type of radiation technique used include sonophoretic/acoustic methods, optical and spectroscopic techniques such as near-infrared and far-infrared spectroscopy, radiowave impedance, skin impedance spectroscopy, polarimetry, Raman spectroscopy, photo acoustic methods and optical coherent tomography. Skin extraction methods include sonophoresis, abrasion techniques and reverse iontophoresis.</p> |
