| 摘要 |
The present invention relates :
- to 2-amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo-[1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamide dihydrochloride salt of formula (II) :
or a tautomer, solvate or hydrate thereof ;
- to methods of preparing said dihydrochloride salt ;
- to said dihydrochloride salt for the treatment and/or prophylaxis of a disease;
- to the use of said dihydrochloride salt for the preparation of a medicament for the treatment and/or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, more particularly for the treatment or prophylaxis of a cancer, particularly lung cancer, in particular non-small cell lung carcinoma, colorectal cancer, melanoma, pancreatic cancer, hepatocyte carcinoma, pancreatic cancer, hepatocyte carcinoma or breast cancer ;
- to a pharmaceutical composition comprising said dihydrochloride salt ; and
- to a pharmaceutical combination comprising said dihydrochloride salt in combination with one or more further pharmaceutical agents. |
