发明名称 |
METHODS AND COMPOSITIONS FOR PREDICTING RESISTANCE TO ANTICANCER TREATMENT WITH PROTEIN KINASE INHIBITORS |
摘要 |
<p>The instant application provides methods and related compositions pertaining to the identification of resistance to anticancer treatment in a patient. In a particular embodiment, the invention provides biomarkers for the identification of resistance to anticancer treatment in a lung cancer patient, wherein a reduced expression of a MEDIATOR and/or SW1/SNF complex gene in the lung cancer cells of the patient indicates that the lung cancer cells in the patient may be resistant to treatment with a receptor tyrosine kinase inhibitor, such as gefitinib and/or erlotinib. In some embodiments, the invention relates to methods and related compositions for predicting resistance to anticancer treatment by detecting the expression levels of one or more TGF-beta pathway nucleic acids and/or proteins.</p> |
申请公布号 |
EP2694677(A2) |
申请公布日期 |
2014.02.12 |
申请号 |
EP20120716857 |
申请日期 |
2012.04.04 |
申请人 |
NETHERLAND CANCER INSTITUTE |
发明人 |
BERNARDS, RENE;HUANG, SIDONG;HOLZEL, MICHAEL |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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