发明名称 |
MICRO-FLUIDIC SYSTEM USING MICRO-APERTURES FOR HIGH THROUGHPUT DETECTION OF ENTITIES |
摘要 |
A microfluidic detection system for micrometer-sized entities, such as biological cells, includes a detector component incorporating a plate with a plurality of opening, the plate separating two chambers, one in communication with a fluid source containing target cells bound to magnetic beads. The openings are sized to always permit passage of the magnetic beads therethrough into a lower one of the chambers and are further sized to always prevent passage of the target cells from the upper one of the chambers. The detector component further includes a magnet positioned to pull unbound magnetic beads through the openings and to capture target cells bound to magnetic beads on the surface of the plate. The microfluidic detection system includes a pump flowing the fluid through the detector component at high flow rates of milliliters per minute for high throughput detection of target cells. |
申请公布号 |
EP2694965(A2) |
申请公布日期 |
2014.02.12 |
申请号 |
EP20120768609 |
申请日期 |
2012.04.05 |
申请人 |
PURDUE RESEARCH FOUNDATION |
发明人 |
SAVRAN, CAGRI, A.;LOW, PHILIP, S.;CHANG, CHUN-LI |
分类号 |
G01N33/50;B01L3/00;G01N1/40;G01N27/72;G01N27/74;G01N33/52;G01N33/543;G01N33/574 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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