发明名称 |
BIOCOMPATIBLE POLYCAPROLACTONE FUMARATE FORMULATIONS |
摘要 |
<p>A polycaprolactone fumarate polymer useful as a matrix material for a biocompatible scaffold for tissue engineering applications is disclosed. The polycaprolactone fumarate polymer can be prepared by reacting caprolactone with an alkane polyol to prepare a polycaprolactone precursor, and then reacting the polycaprolactone precursor with fumaric acid or a salt thereof to prepare the polycaprolactone fumarate polymer. The use of an alkane diol, such as 1,2-propanediol, provides a linear polycaprolactone diol precursor. The use of an alkane triol, such as glycerol, provides a branched polycaprolactone triol precursor. The biocompatible polycaprolactone fumarate formulation releases no diethylene glycol or other undesirable byproducts during degradation.</p> |
申请公布号 |
EP2694587(A1) |
申请公布日期 |
2014.02.12 |
申请号 |
EP20120768537 |
申请日期 |
2012.04.04 |
申请人 |
MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH |
发明人 |
RUNGE, MICHAEL, BRETT;YASZEMSKI, MICHAEL, J. |
分类号 |
C08L67/04;A61L27/18;A61L27/26;C08G63/08;C08G63/60;C08L67/06 |
主分类号 |
C08L67/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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