发明名称 |
ANTIBODY POLYPEPTIDES THAT ANTAGONIZE CD40. |
摘要 |
Antibody polypeptides that specifically bind a novel epitope of human CD40 are provided. The antibody polypeptides do not exhibit CD40 agonist activity. The antibody polypeptides are useful in the treatment of diseases involving CD40 activation, such as autoimmune diseases. The antibody polypeptides may be domain antibodies (dAbs) comprising a single VL or VH domain. The half-life of the antibody polypeptides may be increased by modifying the antibody polypeptides to be dual specific reagents that can also bind human serum albumin (HSA). |
申请公布号 |
MX2013011966(A) |
申请公布日期 |
2014.02.11 |
申请号 |
MX20130011966 |
申请日期 |
2012.04.20 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
ANISH SURI;STEVEN SHERIFF;SUZANNE SUCHARD;AARON YAMNIUK;STANLEY KRYSTEK;JAMES TAMURA;JAMES BRYSON;STEVEN GRANT;PHILIP DREW |
分类号 |
C07K16/28;A61K39/395 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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