| 发明名称 |
ABLAÇÃO GENÉTICA DE CÉLULAS COM GENE PRP USANDO UMA ESTRATÉGIA DE CAPTURA DE PROMOTOR DIRECIONADA PARA A PRODUÇÃO DE PROTEÍNAS RECOMBINANTES ISENTAS DE SORO COMO PRODUTOS TERAPÊUTICOS. |
| 摘要 |
<p>The present invention provides a prion protein (PrP)-free immortalized somatic human cell line wherein both alleles of the PrP gene have been completely deleted by homologous recombination. The invention further provides a method for the production of said cell line and its use for producing human recombinant proteins which are suitable as biopharmaceuticals.</p> |
| 申请公布号 |
BRPI0718989(A2) |
申请公布日期 |
2014.02.11 |
| 申请号 |
BR2007PI18989 |
申请日期 |
2007.11.20 |
| 申请人 |
OCTAGENE GMBH |
发明人 |
CAROLA SCHROEDER;ELISABETH CASADEMUNT;KIM BJOERNSTRUP |
| 分类号 |
C12N15/10;C12N5/071;C12N5/10 |
主分类号 |
C12N15/10 |
| 代理机构 |
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