| 摘要 |
The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein A, R1, R2, R3 and m, are defined in the description. The present invention relates also to methods of making said compounds, and compositions containing said compounds which are useful for inhibiting kinases such as Glycogen Synthase kinase 3 (GSK-3), Rho kinase (ROCK), Janus Kinases (JAK), Cdc7, AKT, PAK4, PLK, CK2, KDR, MK2, JNK1, aurora, pim 1 and nek 2. |
| 申请人 |
AKRITOPOULOU-ZANZE IRINI;WAKEFIELD BRIAN D.;MACK HELMUT;TURNER SEAN C.;GASIECKI ALAN F.;GRACIAS VIJAYA J.;SARRIS KATHY A.;KALVIN DOUGLAS M.;MICHMERHUIZEN MELISSA J.;SHUAI QI;PATEL JYOTI R.;BAKKER MARGARETHA;TEUSCH NICOLE;JOHNSON ERIC F.;KOVAR PETER J.;DJURIC STEVAN W.;LONG ANDREW J.;VASUDEVAN ANIL;GEORGE DAWN;WANG LU;LI BIQIN;MOORE N. ST. JOHN;HOBSON ADRIAN D.;WOODS KEITH W.;MIYASHIRO JULIE M.;SWANN, JR. STEVEN L.;PENNING THOMAS D.;ABBVIE INC. |
发明人 |
AKRITOPOULOU-ZANZE IRINI;WAKEFIELD BRIAN D.;MACK HELMUT;TURNER SEAN C.;GASIECKI ALAN F.;GRACIAS VIJAYA J.;SARRIS KATHY A.;KALVIN DOUGLAS M.;MICHMERHUIZEN MELISSA J.;SHUAI QI;PATEL JYOTI R.;BAKKER MARGARETHA;TEUSCH NICOLE;JOHNSON ERIC F.;KOVAR PETER J.;DJURIC STEVAN W.;LONG ANDREW J.;VASUDEVAN ANIL;GEORGE DAWN;WANG LU;LI BIQIN;MOORE N. ST. JOHN;HOBSON ADRIAN D.;WOODS KEITH W.;MIYASHIRO JULIE M.;SWANN, JR. STEVEN L.;PENNING THOMAS D. |
