发明名称 |
MEANS AND METHODS FOR INFLUENCING THE STABILITY OF ANTIBODY PRODUCING CELLS |
摘要 |
The invention provides methods for increasing the replicative life span and/or stability of an antibody producing cell, comprising
- providing said antibody producing cell with a compound capable of directly or indirectly enhancing BCL6 expression and/or culturing said antibody producing cell in the presence of a compound capable of directly or indirectly enhancing BCL6 expression; and
- directly or indirectly increasing the amount of Bcl-xL or another anti-apoptotic gene expression product within said antibody producing cell. Stable antibody producing cells and cell lines are also provided, as well as methods for producing antibodies using such cells and/or cell lines. |
申请公布号 |
PT1974017(E) |
申请公布日期 |
2014.02.11 |
申请号 |
PT20060824300T |
申请日期 |
2006.12.08 |
申请人 |
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM;AIMM THERAPEUTICS B.V. |
发明人 |
HERGEN SPITS;FERENC ALEXANDER SCHEEREN;TIM BEAUMONT;SEAN ANDREW DIEHL |
分类号 |
C12N5/0781;C12N5/10 |
主分类号 |
C12N5/0781 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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