发明名称 |
MÉTODO PARA PREPARAR UM DERIVADO DE FENILALANINA, E, COMPOSTO |
摘要 |
<p>A method for preparing a phenylalanine derivative having a quinazoline-dione ring represented by the following formula (1) or a pharmaceutically acceptable salt thereof, comprising the following steps (a), (b) and (c):
(a) reacting an acyl phenylalanine derivative represented by the following formula (2):
with a carbonyl group-introducing reagent and a specific anthranilic acid derivative to thus form the corresponding carboxy-asymmetric urea derivative;
(b) converting the carboxy-asymmetric urea derivative into the corresponding quinazoline-dione derivative in the presence of a carboxyl group-activating agent:
(c) if desired, substituting an N-alkyl group for the hydrogen atom bonded to the nitrogen atom present in the quinazoline-dione ring of the quinazoline-dione derivative using an N-alkylation agent and then deprotecting the resulting product, when the substituent R3' which is a group corresponding to R3 is protected. According to this method, there can be obtained a phenylalanine derivative having a quinazoline-dione skeleton in a industrially favorably high yield.</p> |
申请公布号 |
BRPI0718988(A2) |
申请公布日期 |
2014.02.11 |
申请号 |
BR2007PI18988 |
申请日期 |
2007.11.22 |
申请人 |
AJINOMOTO CO., INC. |
发明人 |
NORIYASU KATAOKA;KOTARO OKADO;TATSUHIRO YAMADA;KOICHI FUJITA;TAMOTSU SUZUKI;TATSUYA OKUZUMI;MASAYUKI SUGIKI;AKINORI TATARA |
分类号 |
C07D239/96;C07C233/51;C07C237/40;C07C265/12;C07C271/22;C07C271/28;C07C275/42 |
主分类号 |
C07D239/96 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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