发明名称 |
NANOPARTICLE-BASED TUMOR-TARGETED DRUG DELIVERY |
摘要 |
The present invention provides an aqueous tumor-targeting liposome nanoparticle composition comprising an aqueous dispersion of liposome nanoparticles. The nanoparticles preferably encapsulate an anti-cancer chemotherapeutic agent, which can be added to a pre-formed liposome composition or can be incorporated in the liposomes during the formation of the liposomes. The liposome nanoparticles comprise a legumain-targeting lipid admixed with one or more other micelle or vesicle-forming lipid materials in the form of nanoparticulate liposomes dispersed in an aqueous carrier. A preferred tumor-targeting liposome nanoparticle composition comprises (a) a legumain-targeting lipid component, (b) a zwitterionic lipid component; (c) an amino-substituted lipid component; (d) a neutral lipid component; and (e) polyethylene glycol-conjugated lipid component. The legumain-targeting lipid component comprising a hydrophobic lipid portion covalenetly attached to a legumain-binding moiety. |
申请公布号 |
KR20140017486(A) |
申请公布日期 |
2014.02.11 |
申请号 |
KR20137008369 |
申请日期 |
2011.09.02 |
申请人 |
THE SCRIPPS RESEARCH INSTITUTE |
发明人 |
REISFELD RALPH A.;XIANG RONG;LUO YUNPING;LIAO DEBBIE;LIU ZE;CHEN TINGMEI;CHEN SI;LU DAN |
分类号 |
A61K9/127;A61K9/48;A61P35/00 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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