发明名称 Macrocyclic proline derived HCV serine protease inhibitors
摘要 The present invention discloses compounds of Formula I or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
申请公布号 US8648037(B2) 申请公布日期 2014.02.11
申请号 US201113237120 申请日期 2011.09.20
申请人 OR YAT SUN;MA JUN;WANG GUOQIANG;LONG JIANG;WANG BIN;ENANTA PHARMACEUTICALS, INC. 发明人 OR YAT SUN;MA JUN;WANG GUOQIANG;LONG JIANG;WANG BIN
分类号 A61K38/00;A01N37/18 主分类号 A61K38/00
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