发明名称 |
N1-2-thiophene-2-ylethyl-N2-substituted biguanide derivate, preparation method thereof, and pharmaceutical composition containing the same as active ingredients |
摘要 |
The present invention provides an N1-2-thiophen-2-ylethyl-N2-substituted biguanide derivative of formula (I) or a pharmaceutically acceptable salt thereof, a method for preparing same, and a pharmaceutical composition comprising same as an active ingredient. The inventive N1-2-thiophen-2-ylethyl-N2-substituted biguanide derivative exhibits improved blood glucose level- and lipid level-lowering effects even with a reduced dosage as compared to conventional drugs, and thus, it is useful for preventing or treating diabetes, metabolic syndromes such as insulin-independent diabetes, obesity and atherosclerosis, or a P53 gene defect-related cancer. |
申请公布号 |
US8648111(B2) |
申请公布日期 |
2014.02.11 |
申请号 |
US200913123296 |
申请日期 |
2009.10.13 |
申请人 |
KIM SUNG WUK;JUN SUNG SOO;CHEON HYAE GYEONG;KIM KWANG ROK;RHEE SANG DAL;JUNG WON HOON;LEE JONG CHEOL;HANALL BIOPHARMA CO., LTD.;KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY |
发明人 |
KIM SUNG WUK;JUN SUNG SOO;CHEON HYAE GYEONG;KIM KWANG ROK;RHEE SANG DAL;JUNG WON HOON;LEE JONG CHEOL |
分类号 |
A61K31/38;C07D333/20 |
主分类号 |
A61K31/38 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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