发明名称 |
Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin |
摘要 |
The present invention provides a method for inhibiting the proliferation of malignant and/or hyperplastic cells in a subject by administering to the subject a therapeutically effective amount of a guanosine rich oligonucleotide. The present invention also provides oligonucleotides which are capable of being specifically bound to a specific cellular protein which is nucleolin and/or nucleolin in nature, which is implicated in the proliferation of cells, specifically malignant and/or hyperplastic cells, and a method for their selection. |
申请公布号 |
US8648051(B2) |
申请公布日期 |
2014.02.11 |
申请号 |
US20040978032 |
申请日期 |
2004.10.29 |
申请人 |
MILLER DONALD M.;BATES PAULA J.;TRENT JOHN O.;ADVANCED CANCER THERAPEUTICS, LLC |
发明人 |
MILLER DONALD M.;BATES PAULA J.;TRENT JOHN O. |
分类号 |
A61K48/00;G01N33/50;A01N43/04;A61K31/136;A61K31/337;A61K31/475;A61K31/513;A61K31/522;A61K31/573;A61K31/70;A61K31/7048;A61K31/711;A61K33/24;A61K45/00;A61P35/00;A61P43/00;C07H21/02;C07H21/04;C12N15/115;C12Q1/04;C12Q1/68;G01N33/15;G01N33/53;G01N33/566 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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