| 摘要 |
FIELD: chemistry.SUBSTANCE: claimed invention relates to novel quinazolina derivatives, which have benzofurane substituent of formula:in which each of R, R, R, R, Rand Rrepresent H, Rand Rsimilarly represent alkoxy or methoxyethoxy group; Rrepresents alkyl; Rrepresents-C(O)NRR, and each of Rand Rindependently represents H, alkyl, ethyl, substituted with diethylaminogroup, C-Ccycloalkyl, or Rand Rtogether form cycloalkyl; Z represents N; X represents O, S or NR, where R represents H or alkyl.EFFECT: invention relates to pharmaceutical composition, inhibiting KDR, based on said compounds, method of treating associated with angiogenesis disorder, representing cancer, age-related macular degeneration or chronic inflammatory disease, and method of inhibiting activity of growth factor of vessel endothelium.18 cl, 6 ex |
