| 摘要 |
FIELD: medicine.SUBSTANCE: there are presented: a method of treating a disorder associated with the exposure to an alkylating agent specified in a group: sulphur mustard, nitrogen mustard, chlorine gas, 2-chlor-ethylethylsulphide and phosgene gas by introducing an effective amount of tetrakis-N,N-diethylimidazolium porphyrine or a pharmaceutically acceptable salt, particularly AEOL-10150, and a respective method for protection of an individual against toxic effects related to the exposure to the above alkylating agents. The porphirin AEOL-10150 analogue, a free radical acceptor MnTbap keeps the cell viability unchanged in the similar environment.EFFECT: what is shown is achieving the declared applications: prevention of the organ disorders, and organ recovery following the exposure to sulphur mustard.15 cl, 15 dwg |
