HYDRAZIDE-N-ACYLHYDRAZONE COMPOUNDS, METHOD FOR PRODUCING HYDRAZIDE-N-ACYLHYDRAZONE COMPOUNDS, USE OF INTERMEDIATE COMPOUNDS FOR PRODUCING HYDRAZIDE-N-ACYLHYDRAZONES FOF THE TREATMENT OF LEISHMANIASIS AND CHAGAS DISEASE, AND THUS OBTAINED PHARMACEUTICAL COMPOSITIONS

摘要

The invention relates to hydrazide-N-acylhydrazone compounds, to a method for producing hydrazide-N-acylhydrazone compounds, to the use of intermediate compounds for producing hydrazide-N-acylhydrazones for the treatment of leishmaniasis and Chagas disease, and to the thus obtained pharmaceutical compositions. The invention describes, in particular, the production of leishmanicidal and/or trypanocidal compounds that inhibit the cysteine proteinases involved in infectious processes caused by parasites of the Trypanossoma cruzi and Leishmania species. In other words, the invention relates to the development of the series of hydrazide-N-acylhydrazone compounds aimed at providing an active principle for pharmaceutical compositions for the treatment of the various clinical forms of leishmaniasis and Chagas disease; to the development of the series of functionalised hydrazide-N-acylhydrazone derivatives (series III and IV), achieved by molecular hybridization between the LASSBio-1111 (leishmanicidal) prototype and the LASSBio-1064 (trypanocidal) prototype by hybridisation of the aryl-hydrazide subunit of LASSBio-1111 with the functionalised acylhydrazone of LASSBio-1064, producing a new molecular pattern that conjugates leishmanicidal and/or trypanocidal properties.