发明名称 |
SUBSTITUTED 5 - (QUINAZOLIN - 2 - YL) PYRIMIDIN- 2 -AMINE DERIVATIVES USEFUL AS PI3K/MTOR INHIBITORS FOR THE TREATMENT OF CANCER |
摘要 |
<p>The present application provides novel substituted quinazoline and pyrido-pyrimidine compounds of formula (I) and pharmaceutically acceptable salts, prodrugs, and solvates thereof. Also provided are methods for preparing these compounds. These compounds are useful in co-regulating PI3K and/or mTOR activity by administering a therapeutically effective amount of one or more of the compounds to a patient. By doing so, these compounds are effective in treating conditions associated with the dysregulation of the PI3K/AKT/mTOR pathway. Advantageously, these compounds perform as dual PI3K/mTOR inhibitors. A variety of conditions can be treated using these compounds and include diseases which are characterized by inflammation or abnormal cellular proliferation. In one embodiment, the disease is cancer.</p> |
申请公布号 |
WO2014022728(A1) |
申请公布日期 |
2014.02.06 |
申请号 |
WO2013US53327 |
申请日期 |
2013.08.02 |
申请人 |
ENDO PHARMACEUTICALS, INC |
发明人 |
SMITH, ROGER, ASTBURY;VENKATESAN, ARANAPAKAM;BEJUGAM, MALLESHAM;HOSAHALLI, SUBRAMANYA;NANDURI, SRINIVAS |
分类号 |
C07D401/14;A61K31/517;A61P29/00;A61P35/00;C07D239/94;C07D403/14;C07D409/14;C07D471/04 |
主分类号 |
C07D401/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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