MODIFIED MICROORGANISM FOR HIGH EFFICIENT PRODUCTION OF 1,4-BUTANEDIOL

摘要

The present invention relates to a modified microorganism for the highly efficient production of 1,4-butanediol, and a production method of 1,4-butanediol using the modified microorganism. The modified microorganism has improved tolerance against 1,4-butanediol by the loss or destruction of a gene encoding more than one selected from the group consisting of a transcriptional regulatory factor NCgl2886, GCN5-related N-acetyl transferase NCgl2090, hypothetical protein NCgl0224, and sugar phosphate isomerase/epimerase NCgl2956; and enables users to produce 1,4-butanediol in high efficiency even under the presence of the high concentration of 1,4-butanediol.