| 摘要 |
PURPOSE: A Paeonia lactiflora seed extract, a fraction thereof, or a compound isolated therefrom, and a pharmaceutical composition containing the same are provided to suppress the activation of beta-secretase (BECE-1) and to prevent or treat neurodegenerative diseases. CONSTITUTION: A pharmaceutical composition for preventing or treating neurodegenerative diseases contains one or more kinds of compounds selected among compounds of chemical formulas 1-8, as active ingredients. A method for preparing the compounds of chemical formulas 1-8 comprises the steps of: adding water, C1-C4 alcohols, or a mixture thereof to Paeonia lactiflora seeds and obtaining a Paeonia lactiflora seed extract; fractioning the extract with water, dichloromethane, and ethyl acetate and obtaining a fraction; and isolating compounds by performing silicagel column chromatography of the fraction and purifying the compounds. |
