| 发明名称 |
COMPLEX CHROMOSOME ENGINEERING FOR PRODUCTION OF HUMAN ANTIBODIES IN TRANSGENIC ANIMALS |
| 摘要 |
The invention relates to large-scale production of human antibodies by transgenic animals with high production of fully human IgG up to >10 g/L in sera with human IgGl subclass dominancy. This invention also supports a feasibility of complex chromosome engineering for complicated genetic studies in non-murine mammalian species. |
| 申请公布号 |
WO2014022853(A1) |
申请公布日期 |
2014.02.06 |
| 申请号 |
WO2013US53618 |
申请日期 |
2013.08.05 |
| 申请人 |
SANFORD APPLIED BIOSCIENCES, L.L.C. |
发明人 |
KUROIWA, YOSHIMI;MATSUSHITA, HIROAKI;SANO, AKIKO |
| 分类号 |
C07K16/00;A01K67/027;C12N15/85;C12N15/87;C12N15/90 |
主分类号 |
C07K16/00 |
| 代理机构 |
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